checkpoint kinase 2

Preferred Label : checkpoint kinase 2;

MeSH definition : Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.;

MeSH synonym : kinase 2, checkpoint; Checkpoint-Like protein CHK2; CHK2, Checkpoint-Like protein; checkpoint like protein CHK2; protein CHK2, Checkpoint-Like; CHEK2 kinase; kinase, CHEK2; Chk2 protein kinase; kinase, Chk2 protein; protein kinase, Chk2; LFS2 protein kinase; kinase, LFS2 protein; protein kinase, LFS2; PP1425 protein kinase; kinase, PP1425 protein; protein kinase, PP1425; serine threonine protein kinase Chk2; Serine-Threonine-Protein kinase CHK2; CHK2, Serine-Threonine-Protein kinase; kinase CHK2, Serine-Threonine-Protein; CDS1 kinase; kinase, CDS1; hCHK2 kinase; kinase, hCHK2;

CISMeF synonym : 2, checkpoint kinase;

Registry Number MeSH : EC 2.7.1.11;

Is substance : O;

UNII : EC 2.7.1.11;

Details

Origin ID

D064447;

UMLS CUI

C0296594;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Checkpoint kinase 2 [OMIM Phenotype]
- Checkpoint kinase 2 [OMIM gene]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
- checkpoint kinase 2 [ORDO Gene]
- checkpoint kinase 2 [HGNC gene]
Record concept(s)
- checkpoint kinase 2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CHEK2 protein, human [MeSH Supplementary Concept]
- CHK-2 protein, C elegans [MeSH Supplementary Concept]
- Cds1 protein, S pombe [MeSH Supplementary Concept]
- Chek2 protein, mouse [MeSH Supplementary Concept]
- Chek2 protein, rat [MeSH Supplementary Concept]
- RAD53 protein, S cerevisiae [MeSH Supplementary Concept]
- lok protein, drosophila [MeSH Supplementary Concept]
- rad3 protein, S pombe [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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