Checkpoint Kinase Inhibitor AZD7762

Preferred Label : Checkpoint Kinase Inhibitor AZD7762;

NCIt related terms : AZD-7762;

NCIt definition : A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.;

UNII : 5D822Y3L1H;

CAS number : 860352-01-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 860352-01-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZD7762;

Details

Origin ID

C66961;

UMLS CUI

C1832037;

Currated CISMeF NLP mapping
- AZD 7762 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD 7762 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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