Serine/Threonine-Protein Kinase Chk1

Preferred Label : Serine/Threonine-Protein Kinase Chk1;

NCIt synonyms : CHEK1 Protein; CHK1; CHEK1; Cell Cycle Checkpoint Kinase; EC 2.7.1.-; CHK1 Checkpoint Homolog Protein; CHK1 Checkpoint Homolog; Checkpoint Kinase-1; EC 2.7.11.1;

NCIt definition : Serine/threonine-protein kinase Chk1 (476 aa, 54 kDa) is encoded by the human CHEK1 gene. This protein is involved in both DNA damage response and cell cycle regulation.;

NCIt note : Serine/threonine-protein kinase Chk1 binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C on serine-216 creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry.;

Details

Origin ID

C25919;

UMLS CUI

C0659150;

OMIM relation
- Checkpoint kinase 1 [OMIM gene]
See also inter- (CISMeF)
- thymidine kinase 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CHEK1 protein, human [MeSH Supplementary Concept]
- CHEK1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CHEK1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- 7-Hydroxystaurosporine [NCIt concept]
gene_product_expressed_in_tissue
- Colon [NCIt concept]
- Small Intestine [NCIt concept]
- Testis [NCIt concept]
- Thymus Gland [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- CDC25 and CHK1 Regulatory Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- Circadian Rhythm Pathway PID [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- RB Checkpoint Signaling Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Cell Cycle [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- 7-Hydroxystaurosporine [NCIt concept]
- CHK1 Inhibitor MK-8776 [NCIt concept]
- CHK1 Inhibitor PF-477736 [NCIt concept]
- Ceralasertib [NCIt concept]
- Checkpoint Kinase Inhibitor AZD7762 [NCIt concept]
- Checkpoint Kinase Inhibitor XL844 [NCIt concept]
- Chk1 Inhibitor [NCIt concept]
- Chk1 Inhibitor BBI-355 [NCIt concept]
- Chk1 Inhibitor GDC-0425 [NCIt concept]
- Chk1 Inhibitor GDC-0575 [NCIt concept]
- Chk1 Inhibitor LY2880070 [NCIt concept]
- Chk1 Inhibitor PEP07 [NCIt concept]
- Chk1 Inhibitor SRA737 [NCIt concept]
- Prexasertib [NCIt concept]
- Serine/Threonine Kinase Inhibitor CBP501 [NCIt concept]

Keyword's position in hierarchy(ies) :

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