NCIt definition : An orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic
and chemosensitization activities. Upon oral administration, chk1 inhibitor GDC-0425
selectively binds to chk1, thereby preventing activity of chk1 and abrogating the
repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition
of cell cycle arrest, and induction of apoptosis. GDC-0425 may potentiate the cytotoxicity
of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents.
Chk1, an ATP-dependent serine/threonine kinase, mediates cell cycle checkpoint control,
is essential for DNA repair, and plays a key role in resistance to chemotherapeutic
agents.;
UNII : 4N173XZ7SX;
CAS number : 1627539-18-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1627539-18-7
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