Preferred Label : Serine/Threonine Kinase Inhibitor CBP501;
NCIt synonyms : Serine Threonine Kinase Inhibitor CBP501; D-Arginine, 4-Benzoyl-D-phenylalanyl-D-seryl-D-tryptophyl-D-seryl-2,3,4,5,6-pentafluoro-D-phenylalanyl-3-cyclohexyl-D-alanyl-D-arginyl-D-
arginyl-D-arginyl-D-glutaminyl-D-arginyl-; Cdc25C Phosphatase (211-221);
NCIt related terms : CBP-501;
NCIt definition : A peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits
multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate
serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C);
disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation
of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into
the mitotic phase of the cell cycle.;
UNII : XH2662798I;
InChIKey : DEZJGRPRBZSAKI-KMGSDFBDSA-N;
CAS number : 565434-85-7;
Molecule name : CBP 501; CBP-501;
Origin ID : C71529;
UMLS CUI : C1870425;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_target
