MAP Kinase-Activated Protein Kinase 2

Preferred Label : MAP Kinase-Activated Protein Kinase 2;

NCIt synonyms : MAPKAPK-2; MK2; MAPKAP-K2; MAPKAP Kinase 2; EC 2.7.11.1; MAPK-Activated Protein Kinase 2; MK-2;

NCIt definition : MAP kinase-activated protein kinase 2 (400 aa, 46 kDa) is encoded by the human MAPKAPK2 gene. This protein is involved in stress responsive signaling.;

NCIt note : MAP kinase-activated protein kinase 2 translocates to the cytoplasm following phosphorylation and activation. (UniProt);

Details

Origin ID

C114359;

UMLS CUI

C1452441;

Automatic exact mappings (from CISMeF team)
- MAP-kinase-activated kinase 2 [MeSH Supplementary Concept]
- Mitogen-activated protein kinase-activated protein kinase 2 [OMIM gene]
OMIM relation
- Mitogen-activated protein kinase-activated protein kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAPKAPK2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAPKAPK2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- HSP27 Regulation Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
- p38 MAPK/MAPKAP Signaling Pathway [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Post-Transcriptional Regulation [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
is_target
- MK2 Inhibitor ATI-2231 [NCIt concept]
- Serine/Threonine Kinase Inhibitor CBP501 [NCIt concept]
- Zunsemetinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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