Preferred Label : MK2 Inhibitor ATI-2231;
NCIt definition : An orally bioavailable inhibitor of mitogen-activated protein (MAP) kinase-activated
protein kinase 2 (MAPKAPK2; MK2), with potential antineoplastic and chemosensitization
activities. Upon oral administration, MK2 inhibitor ATI-2231 targets and binds to
the p38MAPK-MK2 complex, thereby inhibiting the p38MAPK phosphorylation and activation
of MK2. This inhibits p38MAPK/MK2-mediated signaling pathway, and abrogates the repair
of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell
cycle arrest, and induction of apoptosis, and may potentiate the cytotoxicity of DNA-damaging
agents. MK2, a cell cycle checkpoint kinase, plays an important role in DNA repair.;
Molecule name : ATI 2231; ATI-2231;
NCI Metathesaurus CUI : CL1906969;
Origin ID : C200127;
concept_is_in_subset
- has_target
