p38 MAPK Signaling Pathway BioCarta

Preferred Label : p38 MAPK Signaling Pathway BioCarta;

NCIt related terms : p38 MAPK Signaling Pathway;

Alternative definition : BIOCARTA: p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5. The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_p38mapkPathway;

Détails

Origin ID

C39178;

UMLS CUI

C1515678;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Cell Division Control Protein 42 Homolog [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Heat Shock Protein Beta-1 [NCIt concept]
- MAP Kinase-Activated Protein Kinase 2 [NCIt concept]
- MAP Kinase-Activated Protein Kinase 5 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 5 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Non-Histone Chromosomal Protein HMG-14 [NCIt concept]
- Nuclear Receptor Subfamily 2 Group C Member 2 [NCIt concept]
- Phospholipase A2 [NCIt concept]
- Protein Max [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
pathway_has_gene_element
- ATF2 wt Allele [NCIt concept]
- CDC42 wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HMGN1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- HSPB1 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K5 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPKAPK2 wt Allele [NCIt concept]
- MAPKAPK5 wt Allele [NCIt concept]
- MAX wt Allele [NCIt concept]
- MKNK1 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NR2C2 wt Allele [NCIt concept]
- PLA2G1B wt Allele [NCIt concept]
- PLA2G4A wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

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