Dual Specificity Mitogen-Activated Protein Kinase Kinase 6

Preferred Label : Dual Specificity Mitogen-Activated Protein Kinase Kinase 6;

NCIt synonyms : MAPK/ERK Kinase 6; SAPKK3; MAPKK6; Mitogen-Activated Protein Kinase Kinase 6; MAP2K6; Protein Kinase, Mitogen-Activated, Kinase 6; MAP Kinase Kinase 6; MEK 6; Stress-Activated Protein Kinase Kinase 3; SAPK Kinase 3; MKK6 Protein; SAPKK-3; EC 2.7.12.2;

NCIt definition : Dual specificity mitogen-activated protein kinase kinase 6 (334 aa, 37 kDa) is encoded by the human MAP2K6 gene. This protein plays a role in signal transduction, protein phosphorylation and cellular stress response.;

Details

Origin ID

C26485;

UMLS CUI

C1435639;

Currated CISMeF NLP mapping
- MAP kinase kinase 6 [MeSH Descriptor]
- MAP kinase kinase 6 [MeSH concept]
OMIM relation
- Mitogen-activated protein kinase kinase 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP2K6 protein, human [MeSH concept]
- MAP2K6 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MAP2K6 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Liver [NCIt concept]
- Pancreas [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Androgen Receptor Regulation Pathway [NCIt concept]
- Cellular Anthrax Toxin Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Regulation of p38-alpha and p38-beta Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
- Th2 Cytokine Gene Induction Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGFR1 and VEGFR2 Signaling [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
- p38-gamma and p38-delta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Survival [NCIt concept]
- Negative Regulation of Cell Cycle [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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