IL1R Signaling Pathway

Preferred Label : IL1R Signaling Pathway;

NCIt related terms : Signal transduction through IL1R;

Alternative definition : BIOCARTA: Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptionally inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 signaling is opposed by the naturally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. The type 1 IL-1 receptor protein binds IL-1 beta but requires the IL-1 receptor accessory protein (IL-1RAcP) to transduce a signal. IL-1 binding causes activation of two kinases, IRAK-1 and IRAK-2, associated with the IL-1 receptor complex. IRAK-1 (IL-1 Receptor Associated Kinase) activates and recruits TRAF6 to the IL-1 receptor complex. TRAF6 activates two pathways, one leading to NF-kB activation and another leading to c-jun activation. The TRAF associated protein ECSIT leads to c-Jun activation through the Map kinase/JNK signaling system. TRAF6 also signals through the TAB1/TAK1 kinases to trigger the degradation of I-kB, and activation of NF-kB. The IL-1 signaling cascade represents a highly conserved response to pathogens through evolution, with homologs in insects and even in plants. The signal transduction cascade utilized by IL-1 receptor is similar to that of TNF, resulting in NF-kB activation, and is most similar to that of the Toll-like receptors that also participate in inflammatory signaling responses to pathogen components like endotoxin (see Toll-like receptor pathway). (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il1rPathway;

Details

Origin ID

C39120;

UMLS CUI

C1512591;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interferon Alpha-1/13 [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor Antagonist Protein [NCIt concept]
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 3 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase-Like 2 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- TGF-Beta-Activated Kinase 1 and MAP3K7-Binding Protein 1 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Toll-Interacting Protein [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
pathway_has_gene_element
- CHUK wt Allele [NCIt concept]
- IFNA13 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL1R1 wt Allele [NCIt concept]
- IL1RN wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IRAK1 wt Allele [NCIt concept]
- IRAK2 wt Allele [NCIt concept]
- IRAK3 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAP4K4 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- TAB1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TOLLIP wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients