Preferred Label : RELA wt Allele;
NCIt synonyms : RELA; NFKB3; v-REL Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of Kappa Light
Polypeptide Gene Enhancer in B-Cells 3, p65 (Avian) Gene; p65; v-REL Avian Reticuloendotheliosis Viral Oncogene Homolog A Gene; RELA Proto-Oncogene, NF-KB Subunit wt Allele; v-Rel Reticuloendotheliosis Viral Oncogene Homolog A Gene;
NCIt definition : Human RELA wild-type allele is located in the vicinity of 11q13 and is approximately
9 kb in length. This allele, which encodes transcription factor p65 protein, plays
a role in the modulation of transcription by RNA polymerase II. Infrequently, lymphoproliferative
disorders are associated with the translocation t(11;14)(q14;q32) of this gene. Amplification
or increased expression of this gene has also been noted in some cases of squamous
carcinomas of the head and neck and adenocarcinomas of the breast and stomach.;
NCIt note : The RELA gene product is a subunit of the nuclear factor kappa-B complex, a second
messenger which activates the transcription of a number of genes in multiple tissues.
The active form of the transcription factor p65 protein is a homodimer with nuclear
factor kappa B polypeptides p50 or p52, which are capable of activating transcription
in the nucleus. Under ordinary circumstances, p65 is found in the cytosol as a component
of the nuclear factor kappa B protein complex associated with the inhibitory factor
I kappa B. Activation releases the nuclear factor kappa B proteins from I kappa B
and allows their nuclear import, resulting in transcriptional activation.;
GenBank Accession Number : NM_021975;
Origin ID : C53116;
UMLS CUI : C1704704;
False automatic mappings
- Rela [ICD-11 Extension code]
- OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
