IRAK2 wt Allele

Preferred Label : IRAK2 wt Allele;

NCIt synonyms : Interleukin-1 Receptor-Associated Kinase 2 wt Allele; IRAK-2;

NCIt definition : Human IRAK2 wild-type allele is located in the vicinity of 3p25.3 and is approximately 74 kb in length. This allele, which encodes interleukin-1 receptor-associated kinase-like 2 protein, plays a role both in interleukin-1-induced up-regulation of the transcription factor NF-kappa B and in regulation of responsiveness to bacterial endotoxins.;

NCIt note : IRAK2 gene expression is regulated by binding of the transcription factor chromatin insulator protein (CTCF) to a high-affinity binding site in the promoter region of this gene. The IRAK2 gene is expressed in the kidneys, liver, lungs, pancreas, peripheral leukocytes, prostate gland, spleen, thymus, and skeletal muscle.;

GenBank Accession Number : NM_001570;

Details

Origin ID

C51208;

UMLS CUI

C1706329;

OMIM relation
- Interleukin 1 receptor-associated kinase 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 3: 10181630-10255723 [NCIt concept]
gene_in_chromosomal_location
- 3p25.3 [NCIt concept]
gene_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients