Apoptosis Pathway

Preferred Label : Apoptosis Pathway;

NCIt related terms : Apoptosis;

Alternative definition : KEGG: Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2 homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.;

NCI Metathesaurus CUI : CL322961;

KEGG ID : hsa04210;

Details

Origin ID

C38784;

UMLS CUI

C4759886;

Automatic exact mappings (from CISMeF team)
- Apoptosis [MedDRA Preferred Term]
- Apoptosis (morphologic abnormality) [SNOMED CT concept]
- apoptosis [MeSH concept]
- apoptosis [IUPAC Term]
- apoptosis [SNOMED Notion]
- apoptosis [MeSH Descriptor]
- apoptosis [COVID-19 Thesaurus concept]
- apoptotic process [GO term]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
UMLS correspondences (same concept)
- Apoptosis [MedDRA Preferred Term]
- Apoptosis (morphologic abnormality) [SNOMED CT concept]
- Programmed cell death [OMIConto structure]
- apoptosis [IUPAC Term]
- apoptosis [Disease (Nov.)]
- apoptosis [MeSH concept]
- apoptosis [MeSH Descriptor]
- apoptosis [SNOMED Notion]
- apoptotic process [GO term]
- programmed cell death [GO term]
has_gene_product_element
- Actin, Cytoplasmic 2 [NCIt concept]
- Activated Caspase-3 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Apoptosis-Inducing Factor 1, Mitochondrial [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Bcl-2-Like Protein 1 [NCIt concept]
- Bcl-2-Like Protein 2 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Beclin-2 [NCIt concept]
- Beta-Nerve Growth Factor [NCIt concept]
- CASP8 and FADD-Like Apoptosis Regulator [NCIt concept]
- CD40 Ligand [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Calpain-1 Catalytic Subunit [NCIt concept]
- Calpain-2 Catalytic Subunit [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Caspase-7 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cytochrome C [NCIt concept]
- Cytokine Receptor Common Subunit Beta [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 1 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase-Like 2 [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-3 Receptor Subunit Alpha [NCIt concept]
- Lamin-A/C [NCIt concept]
- Lamin-B1 [NCIt concept]
- Lymphotoxin-Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Mono-ADP-Ribosyltransferase PARP3 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Spectrin Alpha Chain, Erythrocytic 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Truncated BID [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 10 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10C [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 16 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]
- p53-Induced Death Domain-Containing Protein 1 [NCIt concept]
pathway_has_gene_element
- ACTG1 wt Allele [NCIt concept]
- AIFM1 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BCL2L1 wt Allele [NCIt concept]
- BCL2L2 wt Allele [NCIt concept]
- BECN2 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CAPN1 wt Allele [NCIt concept]
- CAPN2 wt Allele [NCIt concept]
- CASP10 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CFLAR wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CSF2RB wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL1R1 wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL3RA wt Allele [NCIt concept]
- IRAK1 wt Allele [NCIt concept]
- IRAK2 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LMNA wt Allele [NCIt concept]
- LMNB1 wt Allele [NCIt concept]
- LTA wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MCL1 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NGF wt Allele [NCIt concept]
- NGFR wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NTRK1 wt Allele [NCIt concept]
- PARP3 wt Allele [NCIt concept]
- PIDD1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKAR1A wt Allele [NCIt concept]
- PRKAR2A wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- SPTA1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF10A wt Allele [NCIt concept]
- TNFRSF10B wt Allele [NCIt concept]
- TNFRSF10C wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TNFRSF1B wt Allele [NCIt concept]
- TNFSF10 wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients