p53-Induced Death Domain-Containing Protein 1

Preferred Label : p53-Induced Death Domain-Containing Protein 1;

NCIt synonyms : Leucine-Rich Repeat and Death Domain-Containing Protein; EC 3.4.21.-; p53-Induced Death Domain Protein 1; PIDD1; p53-Induced Protein With a Death Domain; p53-Induced Protein With Death Domain; p53-Induced Death Domain Protein; Leucine-Rich Repeats- and Death Domain-Containing Protein;

NCIt definition : p53-induced death domain-containing protein 1 (910 aa, 100 kDa) is encoded by the human PIDD1 gene. This protein plays a role in proteolysis, caspase activation and DNA damage responses.;

NCIt note : p53-induced death domain-containing protein 1 (PIDD1) is autoproteolytically cleaved into a two chain form comprised of fragments PIDD-N and PIDD-C. Upon cleavage of PIDD1, the two chain protein translocates into the nucleus and activates of NF-kappa-B. Further proteolysis of the PIDD-C chain forms PIDD-CC, which mediates the activation of caspase-2. (UniProt);

Details

Origin ID

C181129;

UMLS CUI

C1439061;

Automatic exact mappings (from CISMeF team)
- P53-induced death domain protein 1 [OMIM gene]
- p53-induced death domain protein 1 [HGNC gene]
OMIM relation
- P53-induced death domain protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PIDD1 protein, human [MeSH Supplementary Concept]
- PIDD1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PIDD1 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
- Leucine-Rich Repeat [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Caspase Activation [NCIt concept]
- Cell Death Signaling Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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