Caspase Activation

Preferred Label : Caspase Activation;

NCIt definition : Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.;

Details

Origin ID

C42784;

UMLS CUI

C1159825;

Automatic exact mappings (from CISMeF team)
- cysteine-type endopeptidase activity [GO term]
- cysteine-type endopeptidase activity involved in apoptotic process [GO term]
- obsolete caspase activity [GO term]
Currated CISMeF NLP mapping
- activation of cysteine-type endopeptidase activity involved in apoptotic process [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- activation of cysteine-type endopeptidase activity involved in apoptotic process [GO term]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_involves_gene_product
- Activated Caspase-3 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Apoptosis-Associated Speck-Like Protein Containing A CARD [NCIt concept]
- Apoptosis-Inducing Factor 1, Mitochondrial [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- Bcl-2-Binding Component 3 [NCIt concept]
- Bcl-2-Related Ovarian Killer Protein [NCIt concept]
- CASP8-Associated Protein 2 [NCIt concept]
- Caspase-10 [NCIt concept]
- Death Domain-Containing Protein CRADD [NCIt concept]
- Diablo IAP-Binding Mitochondrial Protein [NCIt concept]
- GRAM Domain-Containing Protein 4 [NCIt concept]
- Granzyme M [NCIt concept]
- Huntingtin-Interacting Protein 1 [NCIt concept]
- NACHT, LRR and PYD Domains-Containing Protein 12 [NCIt concept]
- NLR Family CARD Domain-Containing Protein 4 [NCIt concept]
- Nucleotide-Binding Oligomerization Domain-Containing Protein 1 [NCIt concept]
- Sentrin-Specific Protease 1 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]
- p53-Induced Death Domain-Containing Protein 1 [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
- Post-Translational Regulation [NCIt concept]
process_involves_gene
- AIFM1 Gene [NCIt concept]
- AIFM1 wt Allele [NCIt concept]
- BBC3 Gene [NCIt concept]
- BBC3 wt Allele [NCIt concept]
- BOK Gene [NCIt concept]
- BOK wt Allele [NCIt concept]
- CASP8AP2 Gene [NCIt concept]
- CASP8AP2 wt Allele [NCIt concept]
- CRADD Gene [NCIt concept]
- CRADD wt Allele [NCIt concept]
- DIABLO Gene [NCIt concept]
- DIABLO wt Allele [NCIt concept]
- GRAMD4 Gene [NCIt concept]
- GRAMD4 wt Allele [NCIt concept]
- GZMM Gene [NCIt concept]
- GZMM wt Allele [NCIt concept]
- HIP1 Gene [NCIt concept]
- HIP1 wt Allele [NCIt concept]
- NLRC4 Gene [NCIt concept]
- NLRC4 wt Allele [NCIt concept]
- NLRP12 Gene [NCIt concept]
- NLRP12 wt Allele [NCIt concept]
- NOD1 Gene [NCIt concept]
- NOD1 wt Allele [NCIt concept]
- PIDD1 Gene [NCIt concept]
- PIDD1 wt Allele [NCIt concept]
- PYCARD Gene [NCIt concept]
- PYCARD wt Allele [NCIt concept]
- SENP1 Gene [NCIt concept]
- SENP1 wt Allele [NCIt concept]
- TNFRSF10B Gene [NCIt concept]
- TNFRSF10B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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