Death Domain-Containing Protein CRADD

Preferred Label : Death Domain-Containing Protein CRADD;

NCIt synonyms : CRADD; CASP2 and RIPK1 Domain-Containing Adaptor with Death Domain; Death Domain Containing Protein CRADD; RIP-Associated ICH1/CED3-Homologous Protein with Death Domain; Caspase and RIP Adaptor with Death Domain; Caspase and RIP Adapter With Death Domain; CASP2 and RIPK1 Domain Containing Adaptor with Death Domain; RIP-Associated Protein With a Death Domain; Death Adaptor Molecule RAIDD;

NCIt definition : Death domain-containing protein CRADD (199 aa, 23 kDa) is encoded by the human CRADD gene. This protein plays a role in the activation of caspase-2, which promotes apoptosis.;

Details

Origin ID

C190817;

UMLS CUI

C1430655;

OMIM relation
- Casp2 and ripk1 domain-containing adaptor with death domain [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CRADD protein, human [MeSH Supplementary Concept]
- CRADD protein, human [MeSH concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- CRADD Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]

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