Death Domain - CISMeF

Preferred Label : Death Domain;

NCIt definition : The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and is present in the TNF receptor, FAS, and several downstream signaling molecules. Transmission of the apoptotic signal requires the functional interaction of proteins via the death domain.;

Details

Origin ID

C13438;

UMLS CUI

C1511738;

Automatic exact mappings (from CISMeF team)
- Death Domain [MeSH concept]
- Death Domain [MeSH Descriptor]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- Death Domain [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Ankyrin-2 [NCIt concept]
- CASP8 and FADD-Like Apoptosis Regulator [NCIt concept]
- CASP8 and FADD-Like Apoptosis Regulator Isoform 2 [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- Death Domain-Containing Protein CRADD [NCIt concept]
- Death-Associated Protein Kinase 1 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 3 [NCIt concept]
- MAP Kinase-Activating Death Domain Protein [NCIt concept]
- Nuclear Factor NF-kappa-B p100 Subunit [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 11B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 16 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 21 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 25 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member EDAR [NCIt concept]
- p53-Induced Death Domain-Containing Protein 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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