" /> Tumor Necrosis Factor Receptor Superfamily Member 10B - CISMeF





Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 10B;

NCIt synonyms : TRAILR2; Death Receptor 5; Fas-Like Protein Precursor; Tumor Necrosis Factor Receptor-Like Protein ZTNFR9; Cytotoxic TRAIL Receptor-2; Apoptosis Inducing Protein TRICK2A/2B; TNFRSF10B; P53-Regulated DNA Damage-Inducible Cell Death Receptor (Killer); Death Domain Containing Receptor For TRAIL/Apo-2L; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor-2; CD262 Antigen; TRAILR-2; TNF Receptor Superfamily Member 10b; Fas-Like Protein; Apoptosis Inducing Receptor TRAIL-R2;

NCIt related terms : TRAIL receptor 2; DR5; TRAIL-R2;

NCIt definition : Tumor necrosis factor receptor superfamily member 10B (440 aa, 48 kDa) is encoded by the human TNFRSF10B gene. This protein is involved in the modulation of the caspase cascade.;

Alternative definition : NCI-GLOSS: A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of death receptor 5 on cancer cells may kill more cells.;

NCIt note : Receptor for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL). In contrast to TRAILR1, TRAILR2 mediates apoptosis via the intracellular adaptor molecule FADD. Formation of a complex between TRAIL and receptors DR4 and DR5 triggers apoptosis by inducing the oligomerization of intracellular death domains.;

Codes from synonyms : CDR0000641155; CDR0000641154; CDR0000641153; CDR0000641152; CDR0000641151;

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18/05/2024


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