Preferred Label : DR5-targeting Tetrameric Nanobody Agonist TAS266;
NCIt synonyms : Tetrameric Nanobody Agonist-targeting death receptor 5 TAS266;
NCIt related terms : TAS-266;
NCIt definition : An agonistic tetravalent nanobody, in which the four single, high affinity heavy chain
variable domain (VHH) antibodies are separated by a peptide linker, targeting death
receptor type 5 (DR5), with potential antineoplastic activity. Upon administration,
DR5-targeting tetrameric nanobody agonist TAS266, with its four DR5-specific single-chain
antibodies, specifically binds to and activates DR5 receptors. This results in the
activation of caspase cascades and induction of apoptosis in DR5-expressing tumor
cells. DR5, a cell surface receptor and member of the tumor necrosis factor (TNF)-receptor
superfamily, triggers apoptosis. Compared to certain anti-DR5 antibody agonists, TAS266
shows increased receptor activation.;
UNII : 2ND8DG76YE;
Molecule name : TAS266;
NCI Metathesaurus CUI : CL433974;
Origin ID : C116886;
UMLS CUI : C3896759;
Semantic type(s)
- concept_is_in_subset
- has_target
