NCIt definition : Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by
TNF Family ligands. TNF receptors typically contain intracellular death domains involved
in the formation of a signal transducing death-inducing complex that includes FADD
and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate
NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce
inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act
as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated
cell death. (NCI);