Tumor Necrosis Factor Receptor Superfamily Member 8

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 8;

NCIt synonyms : Ki-1 Antigen; CD30 Antigen; Antigen CD30; CD30L Receptor; TNF Receptor 8; Lymphocyte Activation Antigen CD30; TNF Receptor-8; TNFRSF8; Cytokine Receptor CD30; Lymphoid Activation Antigen CD30;

NCIt related terms : CD30;

NCIt definition : Tumor necrosis factor receptor superfamily member 8 (595 aa, 64 kDa) is encoded by the human TNFRSF8 gene. This protein is involved in ligand-mediated signal transduction, the positive regulation of apoptosis and the inhibition of cell proliferation.;

NCIt note : Tumor necrosis factor receptor superfamily member 8 is a receptor for TNFSF8/CD30L and interacts with the TRAF1, TRAF2, TRAF3, and TRAF5. (UniProt);

Details

Origin ID

C38906;

UMLS CUI

C4281803;

Currated CISMeF NLP mapping
- Ki-1 Antigen [MeSH Descriptor]
- Ki-1 Antigen [MeSH concept]
OMIM relation
- Tumor necrosis factor receptor superfamily, member 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GCT Authorized Value Terminology [NCIt concept]
- GCT Immunohistochemistry Table [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HL Authorized Value Terminology [NCIt concept]
- HL Immunohistochemistry Table [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF8 Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Monoclonal Antibody HeFi-1 [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_of
- Hodgkin Lymphoma [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Acimtamig [NCIt concept]
- Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes [NCIt concept]
- Anti-CD30 Monoclonal Antibody MDX-1401 [NCIt concept]
- Anti-CD30 Monoclonal Antibody XmAb2513 [NCIt concept]
- Anti-CD30/CD3 Bispecific Antibody GEN3017 [NCIt concept]
- Anti-CD30/DM1 Antibody-drug Conjugate F0002 [NCIt concept]
- Autologous Anti-CD30 CAR T Cells HSP-CAR30 [NCIt concept]
- Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes [NCIt concept]
- Autologous CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes [NCIt concept]
- Brentuximab [NCIt concept]
- Brentuximab Vedotin [NCIt concept]
- CD30 CAR-expressing Autologous T Lymphocytes [NCIt concept]
- Human Anti-CD30 CAR-expressing Autologous T-lymphocytes [NCIt concept]
- Iratumumab [NCIt concept]
- Monoclonal Antibody HeFi-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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