Anti-CD30/CD3 Bispecific Antibody GEN3017

Preferred Label : Anti-CD30/CD3 Bispecific Antibody GEN3017;

NCIt synonyms : DuoBody GEN3017; DuoBody CD3xCD30 GEN3017; CD30 x CD3 Bispecific Antibody GEN3017; Anti-CD30/Anti-CD3 Bispecific Antibody GEN3017;

NCIt definition : An Fc-silenced immunoglobulin G1 (IgG1) bispecific monoclonal antibody against the tumor-associated antigen (TAA) CD30 (tumor necrosis factor receptor superfamily member 8; TNFRSF8) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD30/CD3 bispecific antibody GEN3017 targets and binds to both CD30 on the surface of tumor cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells, and induces a cytotoxic T-lymphocyte (CTL) response against CD30-expressing tumor cells. CD30, a member of the tumor necrosis factor receptor superfamily, is overexpressed on the surfaces of certain tumor cells.;

Molecule name : GEN-3017; GEN 3017;

Details

Origin ID

C201524;

chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
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- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
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- Tumor Necrosis Factor Receptor Superfamily Member 8 [NCIt concept]

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