Preferred Label : Anti-CD30 Antibody-drug Conjugate SGN-35C;
NCIt synonyms : ADC SGN-35C; Anti-CD30/TOP1i ADC SGN-35C; Anti-CD30 ADC SGN-35C;
NCIt definition : An antibody-drug conjugate (ADC) composed of brentuximab (cAC10), a chimeric immunoglobulin
G1 (IgG1) monoclonal antibody directed against the tumor necrosis factor (TNF) receptor
CD30 (tumor necrosis factor receptor superfamily, member 8; TNFRSF8), conjugated to
a camptothecin-derived topoisomerase 1 inhibitor (TOP1i), with potential antineoplastic
activity. Upon administration, anti-CD30 ADC SGN-35C targets and binds to CD30 expressed
on tumor cells. Upon binding and internalization, the TOP1i moiety is released, binds
to TOP1 and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of CD30-expressing tumor cells. CD30 may be constitutively expressed in certain B-
and T-cell lymphoma while expression is limited in normal, healthy cells.;
Molecule name : SGN-35C; SGN 35C;
NCI Metathesaurus CUI : CL1928321;
Origin ID : C205624;
concept_is_in_subset
- has_target
