NCIt definition : A tetravalent bispecific antibody directed against human CD30 and the human low affinity
IgG Fc region receptor (FCGR3A; CD16A), with potential immunomodulating and antineoplastic
activities. Upon administration, acimtamig binds to the CD16A expressed on natural
killer (NK) cells with two of its binding sites and to CD30 on CD30-expressing tumor
cells with the other two binding sites, thereby selectively cross-linking tumor and
NK cells. This may result in NK cell activation, antibody-dependent cellular cytotoxicity
(ADCC) and eventually tumor cell lysis. CD30, a cell surface receptor and a member
of the tumor necrosis factor (TNF) receptor superfamily, is overexpressed in hematologic
malignancies; CD16A is specifically expressed on the surface of NK cells.;
UNII : ND470TT8Y3;
CAS number : 2738880-26-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2738880-26-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;