Human Anti-CD30 CAR-expressing Autologous T-lymphocytes - CISMeF
Human Anti-CD30 CAR-expressing Autologous T-lymphocytesNCIt concept
Preferred Label : Human Anti-CD30 CAR-expressing Autologous T-lymphocytes;
NCIt synonyms : Human Anti-CD30 CAR-expressing Autologous T-cells; Human Anti-CD30scFv CAR-expressing Autologous T-lymphocytes;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv)
derived from a human anti-CD30 monoclonal antibody, with potential immunostimulating
and antineoplastic activities. Upon administration, the human anti-CD30 CAR-expressing
autologous T-lymphocytes specifically recognize and bind to CD30-expressing tumor
cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of
the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on
activated lymphocytes and is constitutively expressed in hematologic malignancies.
Compared to CAR-T cells that use murine scFv-based CARs, CAR-T cells containing CARs
with human scFv regions reduces the immunogenicity of the CAR-T cells and may improve
their longevity.;