Brentuximab - CISMeF

Preferred Label : Brentuximab;

NCIt synonyms : Anti-CD30 Monoclonal Antibody; Monoclonal Antibody SGN-30;

NCIt related terms : SGN-30;

NCIt definition : A genetically-engineered, chimeric mouse-human, anti-CD30 monoclonal antibody with potential antineoplastic activity. Brentuximab specifically binds to the receptor CD-30, a member of the tumor necrosis factor receptor super-family, which may be overexpressed on the surfaces of Hodgkin lymphoma cells and anaplastic-large cell lymphoma cells. After binding to CD30, this agent interferes with the G1 phase of the cell cycle, thereby inducing growth arrest and apoptosis in susceptible tumor cell populations.;

Alternative definition : NCI-GLOSS: A monoclonal antibody that binds to cells that have the CD30 antigen on their surface, including Hodgkin disease cells and cells from anaplastic large cell lymphoma, and cutaneous T-cell lymphoma. SGN-30 is being studied in the treatment of cancer. It is a type of monoclonal antibody.;

UNII : C67ORA155P;

CAS number : 775303-41-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 775303-41-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SGN-30; CAC-10;

NSC code : 731636;

Codes from synonyms : CDR0000405812;

Details

Origin ID

C2007;

UMLS CUI

C3247294;

Currated CISMeF NLP mapping
- SGN-30 monoclonal antibody [MeSH concept]
- SGN-30 monoclonal antibody [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 8 [NCIt concept]

Keyword's position in hierarchy(ies) :

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