Autologous Anti-CD30 CAR T Cells HSP-CAR30

Preferred Label : Autologous Anti-CD30 CAR T Cells HSP-CAR30;

NCIt synonyms : Autologous Anti-CD30 CAR-T Cells HSP-CAR30; Autologous CD30-targeting CAR T-cells HSP-CAR30;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD30 CAR T cells HSP-CAR30 specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.;

Molecule name : HSP CAR30; HSP-CAR30;

NCI Metathesaurus CUI : CL1661917;

Details

Origin ID

C179274;

UMLS CUI

C5555574;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 8 [NCIt concept]

Keyword's position in hierarchy(ies) :

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