Preferred Label : Anti-CD30 Antibody-drug Conjugate SGN-35T;
NCIt synonyms : cAC10/MMAE Antibody-drug Conjugate SGN-35T; ADC SGN-35T; Anti-CD30 ADC SGN-35T;
NCIt definition : An antibody-drug conjugate (ADC) composed of brentuximab (cAC10), a chimeric immunoglobuin
G1 (IgG1) monoclonal antibody directed against the tumor necrosis factor (TNF) receptor
CD30 (tumor necrosis factor receptor superfamily, member 8; TNFRSF8) conjugated, via
a protease-cleavable tripeptide linker, comprised of D-leucine-alanine-glutamate (DLAE),
to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic
activity. Upon administration, anti-CD30 ADC SGN-35T targets, binds to and is internalized
by CD30-positive tumor cells. Upon enzymatic cleavage of the cleavable linker, MMAE
is released into the cytosol. MMAE binds to tubulin and inhibits tubulin polymerization,
which results in G2/M phase arrest and tumor cell apoptosis of CD30-expressing tumor
cells. In addition, SGN-35T induces bystander effect in neighboring tumor cells and
immunogenic cell death (ICD). CD30 may be constitutively expressed in certain B- and
T-cell lymphoma while expression is limited in normal, healthy cells. The linkage
system in is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive
cells.;
Molecule name : SGN 35T; SGN-35T;
NCI Metathesaurus CUI : CL1926435;
Origin ID : C204166;
UMLS CUI : C5908035;
Semantic type(s)
- concept_is_in_subset
- has_target
