Preferred Label : Autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-Lymphocytes;
NCIt synonyms : Anti-CD30-CAR/CD28z-CCR4 Retroviral Vector-transduced Autologous T-Cells; ATLCAR.CD30.CCR4 Cells; ATLs Co-expressing CD30-CARCD28zeta and CCR4; CCR4-CAR-CD30-28zeta-specific Autologous T-cells; Autologous CCR4-CAR-CD19-CD28-zeta-transduced T-lymphocytes; ATLCAR.CD30-CD28zeta-CCR4 Cells; SFG.CCR4-CAR.CD30 Autologous T-lymphocytes;
NCIt definition : A preparation of autologous T-lymphocytes (ATL) that have been transduced with the
retroviral vector SFG, a Moloney murine leukemia (Mo-MuLV) virus-based vector, encoding
human C-C chemokine receptor 4 (CCR4), linked via an internal ribosome entry site
(IRES), to a chimeric antigen receptor (CAR) composed of a single chain single-chain
variable fragment (scFv) directed against the CD30 antigen (CAR.CD30) and linked,
via the spacer human IgG1 immunoglobulin heavy constant region (hinge-CH2CH3 region),
to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta)
(CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration
of the autologous CCR4-CD30CAR-CD28-CD3zeta-expressing T-lymphocytes, the expressed
CCR4 on the T-cells allows for enhanced migration of the cells to chemokine-secreting
tumor cells. The expressed CAR.CD30 moiety specifically recognizes and binds to CD30-expressing
tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD30, a cell
surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily,
is transiently expressed on activated lymphocytes and is constitutively expressed
in hematologic malignancies. CCR4, a G-coupled-protein receptor for C-C chemokines
normally expressed on regulatory T-cells (Tregs) but not on cytotoxic T-lymphocytes
(CTLs), is involved in chemokine-mediated cellular migration. The co-expression of
CCR4 on these CTLs may enhance their anti-tumor activity compared to T-lymphocytes
expressing the same CAR-CD30 receptor but without CCR4 expression.;
NCI Metathesaurus CUI : CL555926;
Origin ID : C155293;
UMLS CUI : C4733634;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
