Preferred Label : Allogeneic Anti-CD30 CAR-Epstein-Barr Virus-specific T-lymphocytes;
NCIt synonyms : Allogeneic Anti-CD30 CAR-EBVSTs; Allogeneic Anti-CD30 CAR EBV-specific T Lymphocytes; Allogeneic CD30.CAR-EBVSTs;
NCIt definition : A preparation of allogeneic human Epstein-Barr virus (EBV)-specific T-lymphocytes
(EBVSTs) that have been genetically modified to express a chimeric antigen receptor
(CAR) recognizing the tumor-associated antigen (TAA) cluster of differentiation 30
(CD30), with potential immunostimulating and antineoplastic activities. Upon administration,
allogeneic anti-CD30 CAR-EBVSTs specifically recognize and bind to CD30-expressing
EBV-infected tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor
and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently
expressed on activated lymphocytes and is constitutively expressed in hematologic
malignancies. EBV, a ubiquitous human herpes virus, is associated with various malignancies,
including nasopharyngeal carcinoma, Hodgkin disease, non-Hodgkin lymphoma, and other
lymphomas.;
NCI Metathesaurus CUI : CL1413414;
Origin ID : C175980;
UMLS CUI : C5446902;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
