Preferred Label : Anti-CD30/DM1 Antibody-drug Conjugate F0002;
NCIt synonyms : F0002-ADC; ADC F0002; Anti-CD30/DM1 ADC F0002;
NCIt definition : An antibody drug conjugate (ADC) consisting of a monoclonal antibody directed against
the tumor necrosis factor (TNF) receptor CD30 conjugated, via a nonreducible thioether
linker (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate or SMCC),
to the cytotoxic agent maytansinoid mertansine (DM1), with potential antineoplastic
activity. Upon administration, the monoclonal antibody moiety of F0002 targets and
binds to CD30-expressing tumor cells. Upon cellular uptake and internalization, the
mertansine moiety binds to tubulin and interferes with microtubule assembly and disassembly
dynamics. This inhibits both cell division and the proliferation of tumor cells that
express CD30. Transiently activated during lymphocyte activation, CD30 (tumor necrosis
factor receptor superfamily, member 8; TNFRSF8) may be constitutively expressed in
some hematologic malignancies.;
Molecule name : F 0002; F-0002;
NCI Metathesaurus CUI : CL1406212;
Origin ID : C172064;
UMLS CUI : C5417887;
Semantic type(s)
- concept_is_in_subset
- has_target
