Tumor Necrosis Factor Receptor Superfamily Member 4

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 4;

NCIt synonyms : Antigen CD134; TAX Transcriptionally-Activated Glycoprotein 1 Receptor; OX40; ACT35 Antigen; CD134 Antigen; OX40L Receptor; TNFRSF4;

CISMeF synonym : OX40; CD134; TNFRSF4;

NCIt related terms : OX-40; CD134;

NCIt definition : Tumor necrosis factor receptor superfamily member 4 (277 aa, 29 kDa) is encoded by the human TNFRSF4 gene. This protein plays a role in signal transduction pathways that mediate apoptosis inhibition and inflammatory responses.;

Alternative definition : NCI-GLOSS: A protein being studied in the treatment of cancer. Substances that attach to OX-40 on the surface of T cells (a type of white blood cell) may help the T cells grow and kill more cancer cells. OX-40 is a type of tumor necrosis factor (TNF) receptor.;

Codes from synonyms : CDR0000557358; CDR0000589416;

Details

Origin ID

C94790;

UMLS CUI

C1608540;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TNFRSF4 protein, human [MeSH Supplementary Concept]
- TNFRSF4 protein, human [MeSH concept]
- receptors, OX40 [MeSH concept]
- receptors, ox40 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Downstream Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- OX40 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Activation [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Agonistic Anti-OX40 Monoclonal Antibody INCAGN01949 [NCIt concept]
- Agonistic Anti-OX40 Monoclonal Antibody MEDI6469 [NCIt concept]
- Anti-OX40 Agonist Monoclonal Antibody BAT6026 [NCIt concept]
- Anti-OX40 Agonist Monoclonal Antibody BGB-A445 [NCIt concept]
- Anti-OX40 Agonist Monoclonal Antibody HFB301001 [NCIt concept]
- Anti-OX40 Agonist Monoclonal Antibody YH-002 [NCIt concept]
- Anti-OX40 Antibody BMS 986178 [NCIt concept]
- Anti-OX40 Hexavalent Agonist Antibody INBRX-106 [NCIt concept]
- Anti-OX40 Monoclonal Antibody GSK3174998 [NCIt concept]
- Anti-OX40/CD137 Bispecific Antibody FS120 [NCIt concept]
- Cudarolimab [NCIt concept]
- Efizonerimod [NCIt concept]
- Ivuxolimab [NCIt concept]
- Lipid Nanoparticle Encapsulated OX40L mRNA-2416 [NCIt concept]
- Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L/IL-23/IL-36gamma mRNA-2752 [NCIt concept]
- Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710 [NCIt concept]
- Revdofilimab [NCIt concept]
- Tavolimab [NCIt concept]
- Vonlerolizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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