NCIt synonyms : Efizonerimod Alfa; Immunoglobulin G4 (10-proline) (Human Heavy Chain Fc Fragment) Fusion Protein with
Tumor Necrosis Factor Receptor-associated Factor TRAF2 (Human C-C Domain Fragment)
Fusion Protein with CD252 Antigen (Human Extracellular Domain Fragment), Hexamer;
NCIt definition : An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory
activity. Upon administration, efizonerimod selectively binds to and activates the
OX40 receptor, by mimicking the action of endogenous OX40 ligand (OX40L). OX40 receptor
activation induces proliferation of memory and effector T lymphocytes. In the presence
of tumor-associated antigens (TAAs), this may promote an immune response against the
TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor
necrosis factor (TNF) receptor family, is expressed on T-lymphocytes and provides
a co-stimulatory signal for the proliferation and survival of activated T cells.;