" /> Antibody-Dependent Cellular Cytotoxicity - CISMeF





Preferred Label : Antibody-Dependent Cellular Cytotoxicity;

NCIt synonyms : Antibody-Mediated Lympholysis; ADCC;

NCIt related terms : antibody-dependent cell-mediated cytotoxicity;

NCIt definition : The target killing of a cell depending on antibody recognition. An antibody is directed to the target by antigen-binding arms and anchors to the killer cell by an Fc receptor. The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact. The effector killer cell possesses Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.;

Alternative definition : NCI-GLOSS: A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes.;

Codes from synonyms : CDR0000653101; CDR0000653102; CDR0000653103;

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11/05/2025


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