NCIt definition : A personalized cancer vaccine comprised of a chimpanzee adenovirus vector (ChAdV)
encoding twenty tumor-specific neoantigens (TSNAs) that have been identified through
genetic sequencing of a patient's tumor cells, with potential immunostimulatory and
antineoplastic activities. Upon intramuscular administration of lutadenovec autogene,
the adenovirus infects cells and expresses the TSNAs. This stimulates the host immune
system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
the TSNAs, leading to tumor cell lysis. Adenoviral-TSNA vaccine GRT-C901 is followed
by monthly boosting with a self-amplifying mRNA (SAM) boosting vaccine that encodes
the same 20 target TSNAs. The combined immunotherapy product, consisting of priming
and boosting vaccines, is referred to as GRANITE-001.;