Preferred Label : Fresolimumab;
NCIt synonyms : Human Anti-TGF-Beta Monoclonal Antibody GC1008; Anti-TGF-Beta Monoclonal Antibody GC1008; Immunoglobulin G4, anti-(transforming growth factor beta) (human monoclonal GC-1008
heavy chain), disulfide with human monoclonal GC-1008 light chain, Dimer;
NCIt related terms : GC1008;
NCIt definition : A pan-specific, recombinant, fully human monoclonal antibody directed against human
transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity.
Fresolimumab binds to and inhibits the activity of all isoforms of TGF-beta, which
may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta,
a cytokine often over-expressed in various malignancies, may play an important role
in promoting the growth, progression, and migration of tumor cells.;
Alternative definition : NCI-GLOSS: A monoclonal antibody being studied in the treatment of kidney cancer,
melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory
and can locate and bind to substances in the body, including cancer cells. Anti-TGF-beta
monoclonal antibody GC1008 binds to the protein transforming growth factor-beta (TGF?)
and may block the growth of cancer cells that make it.;
UNII : 375142VBIA;
CAS number : 948564-73-6;
Molecule name : GC1008;
Codes from synonyms : CDR0000527378; CDR0000543499;
Origin ID : C63546;
UMLS CUI : C2987643;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
