Transforming Growth Factor-Beta Superfamily

Preferred Label : Transforming Growth Factor-Beta Superfamily;

NCIt synonyms : Bone-Derived Transforming Growth Factor; TGF-Beta; Milk Growth Factor; TGF B; Transforming Growth Factor-Beta; TGF-B; Tumor Growth Factor Beta; Tumor Growth Factor B; TGF Beta; Transforming Growth Factor Beta;

NCIt definition : A family of structurally-related cytokines that bind to their cognate serine/threonine kinase receptors as homodimers or heterodimers linked by a single disulfide bond. These proteins play a role in embryonic development, hematopoiesis, tissue repair and extracellular matrix remodeling.;

Details

Origin ID

C20455;

UMLS CUI

C0040690;

Currated CISMeF NLP mapping
- Transforming growth factor beta [LOINC component]
- transforming growth factor beta [MeSH Descriptor]
- transforming growth factor beta [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Transforming growth factor beta [LOINC component]
- transforming growth factor beta [MeSH concept]
- transforming growth factor beta [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Recombinant Transforming Growth Factor-Beta [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Fresolimumab [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Transforming Growth Factor [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_chemical_classification_of_gene_product
- Glial Cell Line-Derived Neurotrophic Factor [NCIt concept]
is_target
- Anti-PD-L1/TGF-beta Bispecific Antibody Y101D [NCIt concept]
- Anti-PD-L1/VEGF/TGF-beta Trispecific Antibody DR30206 [NCIt concept]
- Anti-TGF-beta Monoclonal Antibody SAR-439459 [NCIt concept]
- Bifunctional TGF-beta Antagonist/IL-15 Protein Complex HCW9218 [NCIt concept]
- Fresolimumab [NCIt concept]
- Halofuginone [NCIt concept]
- Halofuginone Hydrobromide [NCIt concept]
- Nisevokitug [NCIt concept]

Keyword's position in hierarchy(ies) :

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