NCIt synonyms : Anti-PD-L1/Anti-VEGF/Anti-TGF-beta Trispecific Antibody DR30206; PD-L1 x VEGF x TGF-beta Trispecific Antibody DR30206;
NCIt definition : A trispecific antibody targeting the immunosuppressive ligand programmed cell death-1
ligand 1 (PD-L1; cluster of differentiation 274; CD274), human vascular endothelial
growth factor (VEGF) and human transforming growth factor beta (TGF-beta), with potential
immune checkpoint inhibitory, anti-angiogenic and antineoplastic activities. Upon
administration, anti-PD-L1/VEGF/TGF-beta trispecific antibody DR30206 targets and
simultaneously binds to both PD-L1 and VEGF expressed on tumor cells, and also neutralizes
TGF-beta. This prevents both TGF-beta- and PD-L1-mediated immuno-suppressive pathways
signaling, which increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL)
activities, restores and enhances anti-tumor responses, and inhibits tumor cell proliferation
in susceptible tumor cells. The binding of DR30206 to VEGF prevents the binding of
VEGF to its receptor VEGFR, abrogates VEGF/VEGFR-mediated signaling and may lead to
the inhibition of vascular endothelial cell proliferation. The inhibition of tumor
angiogenesis may further decrease tumor cell proliferation and prevent metastasis.
VEGF is overexpressed in a variety of cancers and is associated with increased invasiveness
and decreased survival. TGF-beta and PD-L1 are both upregulated in certain types of
cancers; their overexpression is associated with increased evasion of immune surveillance
and contributes to poor prognosis.;
Semantic type(s)