Programmed Cell Death 1 Ligand 1

Preferred Label : Programmed Cell Death 1 Ligand 1;

NCIt synonyms : PDL1; Programmed Death Ligand 1; CD Antigen CD274; B7 Homolog 1; B7-H1; Pdcd1 Ligand 1; CD274; CD274 Antigen; PD-L1;

NCIt definition : Programmed cell death 1 ligand 1 (290 aa, 33 kDa) is encoded by the human CD274 gene. This protein is involved in the mediation of both the activation and proliferation of T cells.;

Details

Origin ID

C96024;

UMLS CUI

C0965245;

Automatic exact mappings (from CISMeF team)
- B7-H1 Antigen [MeSH Descriptor]
- B7-H1 Antigen [MeSH concept]
- CD274 molecule [HGNC gene]
- Cd274 molecule [OMIM gene]
OMIM relation
- Cd274 molecule [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CD274 protein, human [MeSH concept]
- CD274 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CD274 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Intracellular Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Immunoglobulin-Like V-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- T-Cell Proliferation [NCIt concept]
is_target
- Acasunlimab [NCIt concept]
- Adebrelimab [NCIt concept]
- Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells [NCIt concept]
- Anti-4-1BB/PD-L1 Bispecific Antibody PM1003 [NCIt concept]
- Anti-CD137/PD-L1 Bispecific Antibody AP203 [NCIt concept]
- Anti-CD137/PD-L1 Bispecific Antibody FS222 [NCIt concept]
- Anti-CD47/Anti-PD-L1 Bispecific Antibody 6MW3211 [NCIt concept]
- Anti-CD47/Anti-PD-L1 Bispecific Antibody PF-07257876 [NCIt concept]
- Anti-CLDN18.2/Anti-PD-L1 CAR-T Cells [NCIt concept]
- Anti-CLDN6/CD3 BiTE Antibody AMG 794 [NCIt concept]
- Anti-GARP/PD-L1 Bispecific Antibody BPB-101 [NCIt concept]
- Anti-LAG-3/Anti-PD-L1 Bispecific Antibody IBI323 [NCIt concept]
- Anti-LAG-3/PD-L1 Bispecific Antibody FS118 [NCIt concept]
- Anti-PD-1-IL-15 Prodrug Fusion Molecule ASKG915 [NCIt concept]
- Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V [NCIt concept]
- Anti-PD-L1 Antibody/IL-15 Fusion Protein IGM-7354 [NCIt concept]
- Anti-PD-L1 Monoclonal Antibody FAZ053 [NCIt concept]
- Anti-PD-L1 Monoclonal Antibody GR1405 [NCIt concept]
- Anti-PD-L1 Monoclonal Antibody LP002 [NCIt concept]
- Anti-PD-L1 Monoclonal Antibody MDX-1105 [NCIt concept]
- Anti-PD-L1 Monoclonal Antibody RC98 [NCIt concept]
- Anti-PD-L1/4-1BB Bispecific Antibody QLF31907 [NCIt concept]
- Anti-PD-L1/Anti-4-1BB Bispecific Antibody ABL503 [NCIt concept]
- Anti-PD-L1/Anti-CD47 Bispecific Antibody BAT7104 [NCIt concept]
- Anti-PD-L1/Anti-CD47 Bispecific Monoclonal Antibody LB101 [NCIt concept]
- Anti-PD-L1/Anti-LAG-3 Bispecific Antibody ABL501 [NCIt concept]
- Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09 [NCIt concept]
- Anti-PD-L1/Anti-TGF-beta Bifunctional Fusion Protein TQB2858 [NCIt concept]
- Anti-PD-L1/Anti-TIGIT Bispecific Antibody PM1022 [NCIt concept]
- Anti-PD-L1/Anti-VEGF Bispecific Antibody Fusion Protein B1962 [NCIt concept]
- Anti-PD-L1/Anti-VEGF-A Bispecific Antibody PM8002 [NCIt concept]
- Anti-PD-L1/CD137 Bispecific Antibody MCLA-145 [NCIt concept]
- Anti-PD-L1/CD27 Bispecific Antibody CDX-527 [NCIt concept]
- Anti-PD-L1/Claudin18.2 Bispecific Antibody Q-1802 [NCIt concept]
- Anti-PD-L1/IL-15 Fusion Protein KD033 [NCIt concept]
- Anti-PD-L1/IL-15 Fusion Protein SIM0237 [NCIt concept]
- Anti-PD-L1/PD-L2 Bispecific Antibody IMGS-001 [NCIt concept]
- Anti-PD-L1/TGF-beta Bispecific Antibody Y101D [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511 [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005 [NCIt concept]
- Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244 [NCIt concept]
- Anti-TIGIT/Anti-PD-L1 Bispecific Antibody HB0036 [NCIt concept]
- Anti-TIGIT/Anti-PD-L1 Bispecific Antibody HLX301 [NCIt concept]
- Antibody receptor-Trap Fusion Protein IMM2520 [NCIt concept]
- Atezolizumab [NCIt concept]
- Atezolizumab and Recombinant Human Hyaluronidase [NCIt concept]
- Autologous 1928T2z CAR T-cells WZTL-002 [NCIt concept]
- Autologous Anti-PD-L1-armored Anti-CD22 CAR T Cells [NCIt concept]
- Avelumab [NCIt concept]
- Benmelstobart [NCIt concept]
- Betifisolimab [NCIt concept]
- Bintrafusp Alfa [NCIt concept]
- Cosibelimab [NCIt concept]
- Danburstotug [NCIt concept]
- Davoceticept [NCIt concept]
- Durvalumab [NCIt concept]
- Emfizatamab [NCIt concept]
- Engineered Toxin Body Targeting PD-L1 MT-6402 [NCIt concept]
- Enristomig [NCIt concept]
- Envafolimab [NCIt concept]
- Erfonrilimab [NCIt concept]
- Fluorine F 18-BMS-986229 [NCIt concept]
- Fluorine F18 BMS-986192 [NCIt concept]
- Garivulimab [NCIt concept]
- HER-2/PD-L1-targeting CAR-T Cells [NCIt concept]
- Lodapolimab [NCIt concept]
- Manelimab [NCIt concept]
- Nab-paclitaxel/Danburstotug Complex AP160 [NCIt concept]
- Nebratamig [NCIt concept]
- Oncolytic Virus CF33-expressing hNIS/Anti-PD-L1 Antibody [NCIt concept]
- Opucolimab [NCIt concept]
- PD-L1 Inhibitor [NCIt concept]
- PD-L1 Inhibitor ABSK043 [NCIt concept]
- PD-L1 Inhibitor AN4005 [NCIt concept]
- PD-L1 Inhibitor BPI-371153 [NCIt concept]
- PD-L1 Inhibitor GS-4224 [NCIt concept]
- PD-L1 Inhibitor INCB086550 [NCIt concept]
- PD-L1 Inhibitor INCB099280 [NCIt concept]
- PD-L1 Inhibitor INCB099318 [NCIt concept]
- PD-L1/4-1BB/HSA Trispecific Fusion Protein NM21-1480 [NCIt concept]
- PD-L1/IDO Peptide Vaccine IO102-103 [NCIt concept]
- PD-L1/PD-L2/VISTA Antagonist CA-170 [NCIt concept]
- Pacmilimab [NCIt concept]
- Reozalimab [NCIt concept]
- Retlirafusp Alfa [NCIt concept]
- Simridarlimab [NCIt concept]
- Socazolimab [NCIt concept]
- Sotiburafusp Alfa [NCIt concept]
- Sugemalimab [NCIt concept]
- Tagitanlimab [NCIt concept]
- Xirestomig [NCIt concept]
- Zirconium Zr 89-DFO-REGN3504 [NCIt concept]
- Zirconium Zr 89-labeled Atezolizumab [NCIt concept]
- mRNA-derived IDO/PD-L1-targeted Vaccine mRNA-4359 [NCIt concept]

Keyword's position in hierarchy(ies) :

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