Preferred Label : Anti-PD-L1/Anti-TGF-beta Bifunctional Fusion Protein TQB2858;
NCIt synonyms : Anti-PD-L1/TGF-beta Bifunctional Fusion Protein TQB2858;
NCIt definition : A bifunctional fusion protein directed against both human programmed death ligand
1 (PD-L1) and transforming growth factor beta (TGF-beta), with potential antineoplastic
and immune checkpoint modulating activities. Upon administration, anti-PD-L1/anti-TGF-beta
bifunctional fusion protein TQB2858 targets, binds to and neutralizes TGF-beta on
tumor cells and simultaneously targets, binds to, and inhibits the activity of PD-L1
on the tumor cells. This prevents both TGF-beta- and PD-L1-mediated immunosuppressive
pathways signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte
(CTL) activities. This also restores and enhances anti-tumor responses and inhibits
tumor cell proliferation in susceptible tumor cells. TGF-beta and PD-L1 are both upregulated
in certain types of cancers; their overexpression is associated with increased evasion
of immune surveillance and contributes to poor prognosis.;
Molecule name : TQB-2858; TQB 2858;
NCI Metathesaurus CUI : CL1773458;
Origin ID : C185119;
UMLS CUI : C5666936;
Semantic type(s)
- concept_is_in_subset
- has_target
