Transforming Growth Factor Beta-3

Preferred Label : Transforming Growth Factor Beta-3;

NCIt synonyms : Transforming Growth Factor-Beta 3; Transforming Growth Factor Beta 3; TGF-Beta-3; TGF-Beta 3; TGFB3;

NCIt definition : Transforming growth factor beta-3 (412 aa, 47 kDa) is encoded by the human TGFB3 gene. This protein is involved in cell proliferation, cell death and embryogenesis.;

NCIt note : Transforming Growth Factor Beta 3, encoded by the TGFB3 gene, is a member of the TGF-beta cytokine family. It is expressed as a disulfide-linked homodimer in a wide variety of mesenchymal tissues during human embryogenesis. Transforming Growth Factor Beta 3 is involved in cell differentiation. (from OMIM, Swiss-Prot and NCI);

Details

Origin ID

C20459;

UMLS CUI

C1703303;

Currated CISMeF NLP mapping
- transforming growth factor beta 3 [ORDO Gene]
- transforming growth factor beta3 [MeSH Descriptor]
- transforming growth factor beta3 [MeSH concept]
OMIM relation
- Transforming growth factor, beta-3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TGFB3 protein, human [MeSH concept]
- TGFB3 protein, human [MeSH Supplementary Concept]
- transforming growth factor beta 3 [ORDO Gene]
- transforming growth factor beta3 [MeSH concept]
- transforming growth factor beta3 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- TGFB3 Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
- Transforming Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Embryogenesis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Organogenesis [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-CD39 Antibody/TGF-beta RII Ectodomain Fusion Protein ES014 [NCIt concept]
- Anti-PD-1/Anti-TGF-beta Bifunctional Fusion Protein TQB2868 [NCIt concept]
- Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890 [NCIt concept]
- Anti-PD-1/TGF-beta RII Bifunctional Fusion Protein JS201 [NCIt concept]
- Anti-PD-1/TGFbRII Fusion Protein LBL-015 [NCIt concept]
- Anti-PD-L1/Anti-TGF-beta Bifunctional Fusion Protein TQB2858 [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511 [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005 [NCIt concept]
- Anti-TIGIT Antibody/TGFbeta-RII Fusion Protein AK130 [NCIt concept]
- Bintrafusp Alfa [NCIt concept]
- Ficerafusp Alfa [NCIt concept]
- Retlirafusp Alfa [NCIt concept]
- TGFbeta Receptor Ectodomain-IgG Fc Fusion Protein BMS-986416 [NCIt concept]

Keyword's position in hierarchy(ies) :

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