Transforming Growth Factor Beta-2

Preferred Label : Transforming Growth Factor Beta-2;

NCIt synonyms : Polyergin; TGF-Beta2; Transforming Growth Factor Beta 2; Glioblastoma-Derived T-Cell Suppressor Factor; Transforming Growth Factor-Beta 2; BSC-1 Cell Growth Inhibitor; TGF-beta-2; Cartilage-Inducing Factor-B; TGFB2; G-TSF; TGF-b2; TGF-Beta 2;

NCIt definition : Transforming growth factor beta-2 (414 aa, 48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.;

NCIt note : TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI);

Details

Origin ID

C20458;

UMLS CUI

C1699342;

Currated CISMeF NLP mapping
- transforming growth factor beta 2 [ORDO Gene]
- transforming growth factor beta2 [MeSH Descriptor]
- transforming growth factor beta2 [MeSH concept]
OMIM relation
- Transforming growth factor, beta-2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TGFB2 protein, human [MeSH Supplementary Concept]
- TGFB2 protein, human [MeSH concept]
- transforming growth factor beta 2 [ORDO Gene]
- transforming growth factor beta2 [MeSH Descriptor]
- transforming growth factor beta2 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- TGFB2 Gene [NCIt concept]
- Transforming Growth Factor-Beta Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Inhibitory Protein [NCIt concept]
- Transforming Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-CD39 Antibody/TGF-beta RII Ectodomain Fusion Protein ES014 [NCIt concept]
- Anti-PD-1/Anti-TGF-beta Bifunctional Fusion Protein TQB2868 [NCIt concept]
- Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890 [NCIt concept]
- Anti-PD-1/TGF-beta RII Bifunctional Fusion Protein JS201 [NCIt concept]
- Anti-PD-1/TGFbRII Fusion Protein LBL-015 [NCIt concept]
- Anti-PD-L1/Anti-TGF-beta Bifunctional Fusion Protein TQB2858 [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511 [NCIt concept]
- Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005 [NCIt concept]
- Anti-TIGIT Antibody/TGFbeta-RII Fusion Protein AK130 [NCIt concept]
- Belagenpumatucel-L [NCIt concept]
- Bintrafusp Alfa [NCIt concept]
- Ficerafusp Alfa [NCIt concept]
- Gemogenovatucel-T [NCIt concept]
- Retlirafusp Alfa [NCIt concept]
- TGF-beta2 Antisense Oligonucleotide TASO-001 [NCIt concept]
- Trabedersen [NCIt concept]

Keyword's position in hierarchy(ies) :

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