" /> Transforming Growth Factor Beta-2 - CISMeF





Preferred Label : Transforming Growth Factor Beta-2;

NCIt synonyms : Polyergin; TGF-Beta2; Transforming Growth Factor Beta 2; Glioblastoma-Derived T-Cell Suppressor Factor; Transforming Growth Factor-Beta 2; BSC-1 Cell Growth Inhibitor; TGF-beta-2; Cartilage-Inducing Factor-B; TGFB2; G-TSF; TGF-b2; TGF-Beta 2;

NCIt definition : Transforming growth factor beta-2 (414 aa, 48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.;

NCIt note : TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI);

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29/07/2025


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