Preferred Label : Anti-PD-1/TGF-beta RII Bifunctional Fusion Protein JS201;
NCIt synonyms : Anti-PD-1/TGF-beta RII Fusion Protein JS201;
NCIt definition : A bifunctional fusion protein targeting both the human negative immunoregulatory checkpoint
receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and human transforming
growth factor beta (TGF-beta; TGFb), with potential immune checkpoint modulating,
immunomodulating and antineoplastic activities. Upon administration, anti-PD-1/TGF-beta
RII bifunctional fusion protein JS201 targets and binds to PD-1 and TGF-beta and prevents
the activation of PD-1 and TGF-beta-mediated signaling pathways in the tumor microenvironment
(TME). This abrogates the PD-1- and TGFb-mediated immunosuppression in the TME, increases
natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities, and inhibits
tumor cell proliferation in susceptible tumor cells. PD-1, an inhibitory receptor
belonging to the immunoglobulin superfamily (IgSF), is expressed on activated T-lymphocytes;
it functions as an immune checkpoint that negatively regulates T-cell activation and
effector function when activated by its ligands, and plays an important role in tumor
evasion from host immunity. TGF-beta, a pro-inflammatory mediator, is upregulated
in certain types of cancers and is involved in cancer cell proliferation, tumor progression
and the suppression of the immune response.;
Molecule name : JS 201; JS-201;
NCI Metathesaurus CUI : CL1663600;
Origin ID : C181027;
UMLS CUI : C5556790;
Semantic type(s)
- concept_is_in_subset
- has_target
