Preferred Label : Anti-PD-1/Anti-TGF-beta Bifunctional Fusion Protein TQB2868;
NCIt synonyms : Anti-PD-1/TGF-beta Bifunctional Fusion Protein TQB2868;
NCIt definition : A bifunctional fusion protein directed against both the negative immunoregulatory
human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and transforming
growth factor beta (TGF-beta; TGFb), with potential immune checkpoint inhibitory and
antineoplastic activities. Upon administration, anti-PD-1/anti-TGF-beta bifunctional
fusion protein TQB2868 targets and binds to PD-1 and TGF-beta and prevents the activation
of PD-1 and TGF-beta-mediated signaling pathways in the tumor microenvironment (TME).
This abrogates PD-1- and TGFb-mediated immunosuppression in the TME, increases natural
killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities, and inhibits tumor cell
proliferation in susceptible tumor cells. PD-1, an inhibitory receptor belonging to
the immunoglobulin superfamily (IgSF), is expressed on activated T-lymphocytes; it
functions as an immune checkpoint that negatively regulates T-cell activation and
effector function when activated by its ligands and plays an important role in tumor
evasion from host immunity. TGF-beta, a pro-inflammatory mediator, is upregulated
in certain types of cancers and is involved in cancer cell proliferation, tumor progression,
migration and invasion, and the suppression of the immune response.;
Molecule name : TQB-2868; TQB 2868;
NCI Metathesaurus CUI : CL1779162;
Origin ID : C186661;
UMLS CUI : C5667074;
Semantic type(s)
- concept_is_in_subset
- has_target
