NCIt synonyms : PD-L1 / TGF-b-targeting Fusion Protein SHR 1701; PDL1 x TGFb-targeting Bifunctional Fusion Protein SHR 1701; Anti-PD-L1/TGF-betaRII Fusion Protein SHR 1701;
NCIt definition : A bifunctional fusion protein composed of an anti-programmed death ligand 1 (PD-L1)
monoclonal antibody bound, via the C-terminal ends of the Fc region, to the N-terminal-truncated
extracellular domain (ECD) of human transforming growth factor beta (TGFbeta) receptor
type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating
activities. Upon administration, retlirafusp alfa targets, binds to and neutralizes
TGFbeta on the tumor cell while the antibody moiety simultaneously targets, binds
to, and inhibits the activity of PD-L1 on the tumor cell. This prevents both TGFbeta-
and PD-L1-mediated immuno-suppressive pathways signaling, and increases natural killer
(NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores and enhances
anti-tumor responses and inhibits tumor cell proliferation in susceptible tumor cells.
TGFbeta and PD-L1 are both upregulated in certain types of cancers; their overexpression
is associated with increased evasion of immune surveillance and contributes to poor
prognosis.;