Preferred Label : Anti-PD-1/Anti-TGFbRII Bispecific Antibody INCA33890;
NCIt synonyms : PD-1 x TGFbR2 Bispecific Antibody INCA33890; Anti-PD-1/TGFbRII Bispecific Antibody INCA33890; PD-1 x TGFbRII Bispecific Antibody INCA33890;
NCIt definition : A bispecific antibody directed against the human negative immunoregulatory checkpoint
receptor programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279) and human transforming
growth factor beta (TGF-beta) receptor II (TGFbRII), with potential immune checkpoint
modulating and antineoplastic activities. Upon administration, anti-PD-1/anti-TGFbRII
bispecific antibody INCA33890 targets and binds to both PD-1 and TGFbRII and prevents
the activation of PD-1 and TGF-beta-mediated signaling pathways in the tumor microenvironment
(TME). The binding of INCA33890 to PD-1 prevents the activation of PD-1 by its ligands,
programmed cell death-1 ligand 1 (PD-L1; CD274) and/or 2 (PD-L2; CD273). This abrogates
T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic
T-lymphocyte (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor
growth. The binding of INCA33890 to TGFbRII prevents the binding of TGF-beta to TGFbRII,
thereby preventing the activation of the TGF-beta-mediated signaling pathway. This
abrogates TGF-beta-mediated immunosuppression in the TME, increases natural killer
(NK) cell and CTL activities, and inhibits tumor cell proliferation in susceptible
tumor cells. PD-1, an inhibitory receptor belonging to the immunoglobulin superfamily
(IgSF), is expressed on activated T-lymphocytes; it functions as an immune checkpoint
that negatively regulates T-cell activation and effector function when activated by
its ligands and plays an important role in tumor evasion from host immunity. TGF-beta,
a pro-inflammatory mediator, is upregulated in certain types of cancers and is involved
in cancer cell proliferation, tumor progression, migration and invasion, and the suppression
of the immune response.;
Molecule name : INCA-33890; INCA 33890;
Origin ID : C201142;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
