NCIt definition : A bifunctional monoclonal antibody targeting both the receptor tyrosine kinase epidermal
growth factor receptor (EGFR) and the pro-inflammatory cytokine human transforming
growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon
administration of ficerafusp alfa, the anti-EGFR moiety targets, binds to and prevents
activation of EGFR-mediated signaling. This leads to an inhibition of EGFR-dependent
downstream pathways and EGFR-dependent tumor cell proliferation and metastasis. The
anti-TGFb moiety targets and binds to TGFb, thereby preventing the activation of TGFb-mediated
signaling pathways. This may inhibit the proliferation of tumor cells in which TGFb
is overactivated. EGFR and TGFb, mutated and/or overexpressed on the surfaces of various
tumor cell types, play key roles in tumor cell proliferation and progression.;
Semantic type(s)