" /> Ficerafusp Alfa - CISMeF





Preferred Label : Ficerafusp Alfa;

NCIt synonyms : Anti-EGFR/TGFb Bispecific Monoclonal Antibody BCA101; Anti-EGFR/TGFb Monoclonal Antibody BCA101; EGFR/TGFb Fusion Monoclonal Antibody BCA101;

NCIt definition : A bifunctional monoclonal antibody targeting both the receptor tyrosine kinase epidermal growth factor receptor (EGFR) and the pro-inflammatory cytokine human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration of ficerafusp alfa, the anti-EGFR moiety targets, binds to and prevents activation of EGFR-mediated signaling. This leads to an inhibition of EGFR-dependent downstream pathways and EGFR-dependent tumor cell proliferation and metastasis. The anti-TGFb moiety targets and binds to TGFb, thereby preventing the activation of TGFb-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGFb is overactivated. EGFR and TGFb, mutated and/or overexpressed on the surfaces of various tumor cell types, play key roles in tumor cell proliferation and progression.;

UNII : LZ88YF62H2;

CAS number : 2764727-44-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2764727-44-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BCA-101; BCA 101; FMAB2;

NCI Metathesaurus CUI : CL1407043;

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15/05/2024


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