TGF-beta Signaling Pathway KEGG

Preferred Label : TGF-beta Signaling Pathway KEGG;

NCIt related terms : TGF-beta signaling pathway;

Alternative definition : KEGG: The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads (R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.;

KEGG ID : hsa04350;

Details

Origin ID

C91522;

UMLS CUI

C2984328;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Activin Receptor Type-1 [NCIt concept]
- Activin Receptor Type-1C [NCIt concept]
- Activin Receptor Type-2A [NCIt concept]
- Activin Receptor Type-2B [NCIt concept]
- Anti-Muellerian Hormone Type-2 Receptor [NCIt concept]
- BMP and Activin Membrane-Bound Inhibitor Homolog [NCIt concept]
- Bone Morphogenetic Protein 2 [NCIt concept]
- Bone Morphogenetic Protein 4 [NCIt concept]
- Bone Morphogenetic Protein 5 [NCIt concept]
- Bone Morphogenetic Protein 6 [NCIt concept]
- Bone Morphogenetic Protein 7 [NCIt concept]
- Bone Morphogenetic Protein 8B [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-1A [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-1B [NCIt concept]
- Bone Morphogenetic Protein Receptor Type-2 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Cullin-1 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-1 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-2 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-3 [NCIt concept]
- DNA-Binding Protein Inhibitor ID-4 [NCIt concept]
- Decorin [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- Fibrillin-1 [NCIt concept]
- Growth/Differentiation Factor 5 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Inhibin Beta A Chain [NCIt concept]
- Inhibin Beta B Chain [NCIt concept]
- Inhibin Beta E Chain [NCIt concept]
- Interferon Gamma [NCIt concept]
- Left-Right Determination Factor 1 [NCIt concept]
- Left-Right Determination Factor 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 1 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 5 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 6 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 7 [NCIt concept]
- Muellerian-Inhibiting Factor [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Nodal Homolog [NCIt concept]
- Pituitary Homeobox 2 [NCIt concept]
- Retinoblastoma-Like Protein 1 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- Ski Oncogene Protein [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transcription Factor Dp-1 [NCIt concept]
- Transcription Factor E2F4 [NCIt concept]
- Transcription Factor E2F5 [NCIt concept]
- Transcription Factor Sp1 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Zinc Finger FYVE Domain-Containing Protein 9 [NCIt concept]
pathway_has_gene_element
- ACVR1 wt Allele [NCIt concept]
- ACVR1C wt Allele [NCIt concept]
- AMH wt Allele [NCIt concept]
- AMHR2 wt Allele [NCIt concept]
- BAMBI wt Allele [NCIt concept]
- BMP2 wt Allele [NCIt concept]
- BMP4 wt Allele [NCIt concept]
- BMP5 wt Allele [NCIt concept]
- BMP6 wt Allele [NCIt concept]
- BMP7 wt Allele [NCIt concept]
- BMP8B wt Allele [NCIt concept]
- BMPR1A wt Allele [NCIt concept]
- BMPR1B wt Allele [NCIt concept]
- BMPR2 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- DCN wt Allele [NCIt concept]
- E2F4 wt Allele [NCIt concept]
- E2F5 wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FBN1 wt Allele [NCIt concept]
- GDF5 wt Allele [NCIt concept]
- ID1 wt Allele [NCIt concept]
- ID2 wt Allele [NCIt concept]
- ID3 wt Allele [NCIt concept]
- ID4 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- INHBA wt Allele [NCIt concept]
- INHBB wt Allele [NCIt concept]
- INHBE wt Allele [NCIt concept]
- LEFTY1 wt Allele [NCIt concept]
- LEFTY2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NODAL wt Allele [NCIt concept]
- PITX2 wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- RBL1 wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- SKI wt Allele [NCIt concept]
- SKP1 wt Allele [NCIt concept]
- SMAD1 wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SMAD5 wt Allele [NCIt concept]
- SMAD6 wt Allele [NCIt concept]
- SMAD7 wt Allele [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SP1 wt Allele [NCIt concept]
- TFDP1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- ZFYVE9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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