" /> Myc Proto-Oncogene Protein - CISMeF





Preferred Label : Myc Proto-Oncogene Protein;

NCIt synonyms : Class E Basic Helix-Loop-Helix Protein 39; MYC Transcription Factor; Transcription Factor p64; c-MYC Protein; MYC; bHLHe39; Proto-Oncogene c-Myc;

NCIt definition : Myc proto-oncogene protein (439 aa, 49 kDa) is encoded by the human MYC gene. This protein plays a role in the regulation of transcription and cell proliferation.;

NCIt note : c-MYC Protein is a DNA-binding protein involved in mediating the cellular response to growth factors. Located predominantly in the nucleus, the MYC protein binds to DNA and activates transcription as part of a heteromeric complex with MAX. MYC activates telomerase by inducing expression of its catalytic subunit TERT, linking cell proliferation and chromosome integrity. MYC also induces transcription of E2F1, E2F2, and E2F3. MYC may also repress gene expression. ZNF151 (MIZ1) interacts with the MYC and N-MYC HLH domains and contains thirteen zinc finger domains and a POZ domain, which acts as a negative regulatory domain for transcription factors. Interaction between MIZ1 and MYC depend on the POZ domain. MYC may activate the inhibitory functions of the MIZ1 POZ domain. Expression of MYC is activated by beta-catenin through TCF4 binding sites. Elevated and constitutive expression of c-MYC proteins can cause tumorigenesis. (OMIM);

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18/05/2024


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