Bladder Cancer Pathway

Preferred Label : Bladder Cancer Pathway;

NCIt related terms : Bladder cancer;

Alternative definition : KEGG: Bladder cancers arise and progress along two distinctive pathways. The first of these is often preceded by simple and papillary hyperplasia and exhibits a tumour morphology that is low-grade, superficial and papillary. Papillary carcinoma has a tendency to recur locally, but rarely invades and metastasizes. These tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. The second tumour pathway is characterized by high-grade muscle-invasive tumours, which either originate from flat carcinoma in situ (CIS)/severe dysplasia or arise de novo. Over half of these tumours show defects in the tumour suppressors p53 and/or the retinoblastoma protein (RB) genes and pathways, and over 50% of these tumours progress to local and distant metastases. Some of the cell cycle-related molecules show evidence of epigenetic modulation through aberrant promoter hypermethylation in invasive bladder cancer. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).;

KEGG ID : hsa05219;

Details

Origin ID

C91458;

UMLS CUI

C2984270;

Automatic exact mappings (from CISMeF team)
- Bladder cancer [PASCAL descriptor]
- Bladder cancer [MedDRA Preferred Term]
- Bladder cancer [OMIM Phenotype]
- Bladder cancer [ORDO Disease]
- Bladder cancer [HPMULTI term]
- Bladder neoplasm [HPO term]
- Malignant tumor of urinary bladder (disorder) [SNOMED CT concept]
- bladder cancer [MedlinePlus Topic]
- urinary bladder cancer [DO Concept]
- urinary bladder neoplasms [MeSH Descriptor]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- 72 kDa Type IV Collagenase [NCIt concept]
- Cadherin-1 [NCIt concept]
- Death-Associated Protein Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Interleukin-8 [NCIt concept]
- Interstitial Collagenase [NCIt concept]
- Matrix Metalloproteinase-9 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Ras Association Domain-Containing Protein 1 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Thymidine Phosphorylase [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
pathway_has_gene_element
- ARAF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- DAPK1 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- FGFR3 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MMP1 wt Allele [NCIt concept]
- MMP2 wt Allele [NCIt concept]
- MMP9 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- RASSF1 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- TYMP wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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